Spending and Utilization Indicators in the New Jersey Medicaid ACO Demonstration Project.

Derek DeLia, Rizie Kumar, Jose Nova, Kristen Lloyd, David Goldin 11/01/2018

This report provides a first assessment of spending and utilization indicators related to the New Jersey Medicaid Accountable Care Organization (ACO) Demonstration Project (NJ P.L. 2011, c.114).


Update on ACO Operations and Care Management Strategies in the New Jersey Medicaid ACO Demonstration Project

Derek DeLia, Michael J. Yedidia, Oliver Lontok 11/01/2018

The New Jersey Medicaid Accountable Care Organization (ACO) Demonstration was implemented over a three-year period beginning on July 1, 2015 and recently, a one-year extension of the Demonstration was recently authorized. Previously published reports provided quantitative and qualitative information about activities leading up to and in the first year of the Demonstration. This report provides a detailed assessment of ACO activities in Demonstration year 2.


Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: A multi-database, international cohort study

Edward Chia Cheng Lai, Ju Young Shin, Kiyoshi Kubota, Kenneth K.C. Man, Byung Joo Park, Nicole Pratt, Elizabeth E. Roughead, Ian C.K. Wong, Yea Huei Kao Yang, Soko Setoguchi Iwata 11/01/2018

Purpose: The safety of nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used in Asia-Pacific countries has had limited study. We assessed the risk of hospitalization for gastrointestinal events with loxoprofen and mefenamic acid compared with other NSAIDs in Asia-Pacific populations. Methods: We conducted a cohort study using a distributed network with a common data model in Australia, Hong Kong, Japan, Korea, and Taiwan. We included patients who initiated diclofenac, loxoprofen, mefenamic acid, or celecoxib and followed them until their first gastrointestinal hospitalization, switch or discontinuation of medication, disenrollment, or end of database coverage. We used Cox proportional hazards models to assess hospitalization risk.


Nurses’ and patients’ appraisals show patient safety in hospitals remains a concern

Linda H. Aiken, Douglas M. Sloane, Hilary Barnes, Jeannie P. Cimiotti, Olga Jarrin Montaner, Matthew D. McHugh 11/01/2018

The Institute of Medicine concluded in To Err Is Human in 1999 that transformation of nurse work environments was needed to reduce patient harm. We studied 535 hospitals in four large states at two points in time between 2005 and 2016 to determine the extent to which their work environments improved, and whether positive changes were associated with greater progress in patient safety.


Correlates of Emergency Department Service Utilization Among U.S. Chinese Older Adults

Dexia Kong, Mengting Li, Yin Ling Irene Wong, Jinjiao Wang, Benjamin C. Sun, Xinqi Dong 10/09/2018

Older adults visit emergency departments (EDs) at a disproportionally higher rate than other age groups. Prior studies examining racial disparities in ED utilization focus on African Americans and Hispanics …


The influence of acculturation level and family relationships on quality of life among U.S. Chinese older adults

Yiwei Chen, Yisheng Peng, Minzhi Ye, Ling Xu, Xinqi Dong 10/02/2018

The present study examined the influence of acculturation level and family relationships (i.e., positive family support and negative family strain) on quality of life (QOL), using the data from the Population Study of ChINese Elderly (PINE) in Chicago (N = 3159). Controlling for sociodemographic variables and health status, it was found that individuals’ acculturation level and positive family support were positively related to QOL, whereas negative family strain was negatively associated with QOL. More importantly, higher acculturation levels were associated with increased protective effects of positive family support and reduced risk effects of negative family strain on QOL among U.S. Chinese older adults.


Advanced imaging and hospice use in end-of-life cancer care

Michaela A. Dinan, Lesley H. Curtis, Soko Setoguchi Iwata, Winson Y. Cheung 10/01/2018

Introduction: Advanced imaging can inform prognosis and may be a mechanism to de-escalate unnecessary end-of-life care in patients with cancer. Associations between greater use of advanced imaging and less-aggressive end-of-life care in real-world practice has not been examined.


Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases

Sudha R. Raman, Kenneth K.C. Man, Shahram Bahmanyar, Anick Berard, Scott Bilder, Takoua Boukhris, Greta Bushnell, Stephen Crystal, Kari Furu, Yea Huei KaoYang, Øystein Karlstad, Helle Kieler, Kiyoshi Kubota, Edward Chia Cheng Lai, Jaana E. Martikainen, Géric Maura, Nicholas Moore, Dolores Montero, Hidefumi Nakamura, Anke Neumann & 13 others 10/01/2018

Background: The use of medications to treat attention deficit hyperactivity disorder (ADHD) has increased, but the prevalence of ADHD medication use across different world regions is not known. Our objective was to determine regional and national prevalences of ADHD medication use in children and adults, with a specific focus on time trends in ADHD medication prevalence.


Tobacco Screening and Counseling in the U.S. Smokers With Mental Health and Substance Use Problems

Hillary Samples, Sachini Bandara, Mark Olfson, Brendan Saloner 10/01/2018

Introduction: Individuals with mental health and substance use problems have higher rates of smoking and tobacco-related morbidity and mortality than the general population. These increased rates can be explained, in part, by lower cessation rates compared with overall declines in tobacco use in recent years. The purpose of this study was to examine tobacco screening and cessation counseling in healthcare settings to compare rates for adults with mental health and substance use problems with those without such problems…


Molecular characterization of near full-length genomes of hepatitis B virus isolated from predominantly HIV infected individuals in Botswana

Motswedi Anderson, Wonderful Tatenda Choga, Sikhulile Moyo, Trevor Graham Bell, Tshepiso Mbangiwa, Bonolo Bonita Phinius, Lynnette Bhebhe, Theresa Kibirige Sebunya, Shahin Lockman, Richard Marlink, Anna Kramvis, Max Essex, Rosemary Mubanga Musonda, Jason Tory Blackard, Simani Gaseitsiwe 09/07/2018

The World Health Organization plans to eliminate hepatitis B and C Infections by 2030. Therefore, there is a need to study and understand hepatitis B virus (HBV) epidemiology and viral evolution further, including evaluating occult (HBsAg-negative) HBV infection (OBI), given that such infections are frequently undiagnosed and rarely treated.


Adaptations of the evidence-based Transitional Care Model in the U.S.

Mary D. Naylor, Karen B. Hirschman, Mark P. Toles, Olga Jarrin, Elizabeth Shaid, Mark V. Pauly 09/01/2018

Despite a growing body of evidence that adaptations of evidence-based interventions (EBI) are ubiquitous, few studies have examined the nature and rationale for modifications to the components of these interventions.


Risks of fatal opioid overdose during the first year following nonfatal overdose

Mark Olfson, Melanie Wall, Shuai Wang, Stephen Crystal, Carlos Blanco 09/01/2018

Background: Little is known about risk factors for repeated opioid overdose and fatal opioid overdose in the first year following nonfatal opioid overdose. Methods: We identified a national retrospective longitudinal cohort of patients aged 18–64 years in the Medicaid program who received a clinical diagnosis of nonfatal opioid overdose. Repeated overdoses and fatal opioid overdoses were measured with the Medicaid record and the National Death Index. Rates of repeat overdose per 1000 person-years and fatal overdose per 100,000 person-years were determined. Hazard ratios of repeated opioid overdose and fatal opioid overdose were estimated by Cox proportional hazards.


In silico analysis of hepatitis B virus occult associated mutations in Botswana using a novel algorithm

Motswedi Anderson, Wonderful T. Choga, Sikhulile Moyo, Trevor Graham Bell, Tshepiso Mbangiwa, Bonolo B. Phinius, Lynette Bhebhe, Theresa K. Sebunya, Joseph Makhema, Richard Marlink, Anna Kramvis, Max Essex, Rosemary M. Musonda, Jason T. Blackard, Simani Gaseitsiwe 09/01/2018

Occult hepatitis B infections (OBI) represent a reservoir of undiagnosed and untreated hepatitis B virus (HBV), hence the need to identify mutations that lead to this phenotype. Functionally characterizing these mutations by in vitro studies is time-consuming and expensive.


Is family relations related to health service utilisation among older immigrants: Evidence from Chinese elderly in the United States

Man Guo, Nadia Sabbagh Steinberg, Xinqi Dong, Agnes Tiwari 08/27/2018

The family is the key for survival and success of the 4.6 million older immigrants in the United States. It is also an overlooked context to understand older immigrants …


Prevalence of Rilpivirine and Etravirine Resistance Mutations in HIV-1 Subtype C-Infected Patients Failing Nevirapine or Efavirenz-Based Combination Antiretroviral Therapy in Botswana

Thabo Diphoko, Simani Gaseitsiwe, Ishmael Kasvosve, Sikhulile Moyo, Harriet Okatch, Rosemary Musonda, Mark Wainberg, Joseph Makhema, Richard Marlink, Vladimir Novitsky, Max Essex 08/01/2018

Rilpivirine (RPV) and Etravirine (ETR) are approved second-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment. There is a cross-resistance HIV mutation profile between first-and second-generation NNRTI drugs. We determined the prevalence of HIV-1 drug resistance mutations (DRMs) to RPV and ETR in Botswana.


Association Between Neighborhood Cohesion and Cancer Screening Utilization in Chinese American Older Adults

Ailian Hei, Melissa A. Simon, Xinqi Dong 07/06/2018

This study aims to examine the association between neighborhood cohesion and cancer screening utilization in a community-dwelling Chinese American older population. Data were drawn from the Population Study of Chinese Elderly including 3159 Chinese American older adults aged 60 and above in the greater Chicago area. Cancer screening utilization was assessed by asking whether participants had undergone colon, breast, cervical, or prostate cancer screening.


Association Between Neighborhood Cohesion and Cancer Screening Utilization in Chinese American Older Adults

Ailian Hei, Melissa A. Simon, Xinqi Dong 07/06/2018

This study aims to examine the association between neighborhood cohesion and cancer screening utilization in a community-dwelling Chinese American older population …


Risk of malignancy associated with paediatric use of tumour necrosis factor inhibitors

Timothy Beukelman, Fenglong Xie, Lang Chen, Daniel Horton, James D. Lewis, Ronac Mamtani, Melissa M. Mannion, Kenneth G. Saag, Jeffrey R. Curtis 07/01/2018

Objective to determine whether tumour necrosis factor inhibitor (tnFi) use is associated with an increased rate of incident malignancy compared with no tnFi use in the treatment of juvenile idiopathic arthritis (JIA), paediatric inflammatory bowel disease (pIBd) and paediatric plaque psoriasis (ppso).


Education and Family Health Care Spending

Alan C. Monheit and Irina B. Grafova 06/20/2018

Michael Grossman’s seminal work on the demand for health extended the concept of a household production function to the commodity “good health.”……


Risk of sudden sensorineural hearing loss in adults using phosphodiesterase type 5 inhibitors: Population-based cohort study

Wei Liu, Patrick J. Antonelli, Philipp Dahm, Tobias Gerhard, Joseph A.C. Delaney, Richard Segal, Stephen Crystal, Almut G. Winterstein 06/01/2018

Purpose: The objective of the study was to determine the risk of sudden sensorineural hearing loss (SNHL) associated with use of phosphodiesterase type 5 (PDE5) inhibitors. Methods: We conducted a retrospective cohort study in the MarketScan Commercial Claims and Encounters Database including adult men who initiated a PDE5 inhibitor (n = 377,722) and 1,957,233 nonusers between 1998 and 2007.


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