Epidemiologic and Statistical Methods for Comparative Effectiveness Research

Mark A. Hlatky, Wolfgang C. Winkelmayer, Soko Setoguchi Iwata

Publish Year: 2013

Observational methods are evolving in response to the widespread availability of data from clinical registries, electronic health records, and administrative databases. These approaches will never eliminate the need for randomized trials, but clearly have a role in evaluating the effect of therapies in unselected populations treated in routine practice. This article reviews several approaches to the analysis of observational data that are in common use, or that may have promise even though they are not yet often applied.

Publisher:
https://doi.org/10.1016/j.hfc.2012.09.007